1,2-Dichloro-4-nitrobenzene → 2-Chloro-1-fluoro-4-nitrobenzene

Participants

Reaction Steps

In a 1-liter flange flask fitted with a distillation bridge and impeller stirrer, 240 g (4.1 mol) of potassium fluoride, 30 g (0.05 mol) of dimethyldi (ethoxypolyoxypropyl methyl ether)ammonium chloride and 30 g of xylene were introduced at 70° C. into the melt of 767 g (4.0 mol) of 3,4-dichloronitrobenzene, and the reaction suspension was azeotropically dried under reduced pressure up to 120° C. 498 g (2.84 mol) of 3-chloro-4-fluoronitrobenzene were isolated. Amount of 3-chloro-4-fluoronitrobenzene formed, according to GC analysis:

Provenance & Evidence