Phthaloyl chloride → 2H-Isoindole-2-carbonitrile, 1,3-dihydro-1,3-dioxo-

Participants

Reaction Conditions

Reaction Steps

N-Cyanophthalimide was prepared, as shown in Reaction 1, under a dry atmosphere from a 1:1 mixture of phthaloyl dichloride and 1,3-bis(trimethylsilyl) carbodiimide using 1,2,4-trimethylbenzene as solvent. Two drops of tin(IV) chloride were added as a catalyst before heating the mixture to 60° C. for six hours. The reaction mixture was cooled, filtered, and washed with chilled toluene giving yellow crystals as product. ##STR6##

Provenance & Evidence