Dicyclohexylcarbodiimide → HCID 18997772, compound

Participants

Reaction Steps

With exclusion of moisture, 0.1 mol of dicyclohexylcarbodiimide in dichloromethane is added to a mixture of 0.1 mol of 2-heptyl-5-p-hydroxyphenyl-1,3,4-thiadiazole and 0.1 mol of optically active 2-methyl-2-butylcyanoacetic acid in 200 mL of dichloromethane, while cooling with ice. The mixture is stirred for a further 12 hours at room temperature, the dicyclohexyl urea is filtered off and 2-[4-(2-cyano-2-methylhexanoyloxy)-phenyl]-5-n-heptyl-1,3,4-thiadiazole is isolated by working up in the usual way.

Provenance & Evidence