Ethyl bromoacetate → HCID 131719228, compound

HRID 2260510Notes

Reaction equation

[NH2:1][C@H:2]([CH3:19])[C@:3]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[Cl:18])([OH:10])[CH2:4][N:5]1[CH:9]=[N:8][CH:7]=[N:6]1.Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C@@:3]([OH:10])([CH2:4][N:5]1[CH:9]=[N:8][CH:7]=[N:6]1)[C@H:2]([NH:1][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH3:19]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 14706470HCID 14706470, compound

Product 1

HCID 131719228HCID 131719228, compound

Procedure

Following the procedure described in reference example 8, but starting from (2R*,3R*)-3-amino-1-(1H-1,2,4-triazol-1-yl)-2-(2,4-dichlorophenyl)-2-butanol (obtained according to patent EP 332387) and using ethyl bromoacetate instead of benzyl bromoacetate, the title compound was obtained in a similar yield.

Sources & evidence

ORD record: ord-0df131243b0c45ae9a3137c7fb558bfc
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05478826

Reaction notes

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