HCID 10031285, compound → HCID 10074621, compound

HRID 2260515Notes

Reaction equation

HRID 2260515 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@:9]([OH:42])([CH2:36][N:37]1[CH:41]=[N:40][CH:39]=[N:38]1)[C@H:10]([N:12]([C:24](=[O:35])[C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=1)[CH2:13][C:14]([O:16]CC1C=CC=CC=1)=[O:15])[CH3:11]>C(O)C.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@:9]([OH:42])([CH2:36][N:37]1[CH:41]=[N:40][CH:39]=[N:38]1)[C@H:10]([N:12]([C:24](=[O:35])[C:25]1[CH:26]=[CH:27][C:28]([C:31]([F:32])([F:34])[F:33])=[CH:29][CH:30]=1)[CH2:13][C:14]([OH:16])=[O:15])[CH3:11]

Participants

4

Reactant 1

HCID 10031285HCID 10031285, compound

Product 1

HCID 10074621HCID 10074621, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of (2R*,3R*)-2-(2,4-difluorophenyl)-3-(N-benzyloxy carbonylmethylamino-N-4-trifluoromethylbenzoylamino)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (3.4 g, 5.7 mmol) (obtained in example 26) in ethanol (90 mL) was added 10% palladium on charcoal (0.8 g) and the mixture was hydrogenated (1 atm) during 2 h. The mixture was filtered and the solvent removed in vacuo to afford the title product as a white solid (2.81 g, 99%).

Workup

  1. customduring 2 h
  2. filtrationThe mixture was filtered
  3. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-d8d3a8e35d8f49058590e45b26948947
Source dataset
uspto-grants-1995_12
Patent number
US05478826

Reaction notes

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