Imidazo[1,2-a]pyridine, 2,8-dimethyl- → HCID 57752624, compound

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Reaction Steps

Using a procedure analogous to Example 16B, 2,8-dimethyl-imidazo[1,2-a]pyridine (J. Chem. Soc. 1951; 2411, 2415), (0.30 g, 2.06 mmol) and 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.71 g, 2.06 mmol) give the title compound (0.48 g, 1.33 mmol, 65%). 1H NMR (CDCl3): δ 0.92 (t, J=7.5 Hz, 3H), 0.93 (t, J=7.5 Hz, 3H), 1.81-1.95 (m, 4H), 2.41 (s, 3H), 2.44 (s, 3H), 2.45 (s, 3H), 2.70 (s, 3H), 3.35-3.43 (m, 1H), 6.65 (t, J=6.6 Hz, 1H0, 6.72 9s, 1H), 7.03 (d, J=6.6 Hz, 1H), 7.40 9d, J=6.6 Hz, 1) ppm. ES-MS (m/z): calcd for C22H27N5 (M+H)+: 362.5. found: 362.2.

Provenance & Evidence