反应详情

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (254 mg) and 4-methyl-3-penten-2-one (5 ml) was refluxed for 5 hours. The reaction mixture was cooled and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from a mixture of ethyl acetate and hexane to give 6,7-dihydro-2-(4-fluorophenyl)-3-(pyridin-4-yl)-5,7,7-trimethylpyrazolo[1,5-a]pyrimidine (83 mg).

1. temperaturewas refluxed for 5 hours
2. temperatureThe reaction mixture was cooled
3. concentrationconcentrated in vacuo
4. customThe residue was purified by column chromatography on silica gel
5. customthe obtained oil was crystallized from a mixture of ethyl acetate and hexane