Bromine → HCID 68856390, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-methyl-benzo[b]thiophene-7-carboxylic acid methyl ester (0.50 g, 2.44 mmol) in CHCl3 (10 mL) is cooled to 0° C., treated with a solution of Br2 (0.13 mL, 2.44 mmol) in CHCl3 (5 mL). The reaction is stirred at 0° C. for 30 min, then at RT overnight. The reaction is diluted with CH2Cl2 (50 mL), washed with 10% Na2S2O3 (2×20 mL); dried with Na2SO4, filtered and concentrated to give the title compound (0.69 g, 2.43 mmol, 100%). 1H NMR (CDCl3): δ 2.58 (s, 3H), 4.02 (s, 3H), 7.50 (t, J=7.9 Hz, 1H), 7.92 (d, J=7.9 Hz, 1H), 8.08 (d, J=7.5 Hz, 1H).

Provenance & Evidence