反应详情

Acetic anhydride (38.4 g) was dropwise added to a solution (200 ml) of (R)-(+)-1-phenylethylamine (30 g) in chloroform under ice-cooling. After completion of the reaction, ice water was added thereto and the mixture was extracted with chloroform. The extract was washed with 1N aqueous solution of sodium hydroxide and water. After drying, the mixture was concentrated under reduced pressure to give crystals, which were recrystallized from isopropyl ether to give 32.2 g of (+)-N-(1-phenylethyl)acetamide. [α]D =+143.5° (ethanol, c=1)

1. temperaturecooling
2. additionwas added
3. extractionthe mixture was extracted with chloroform
4. washThe extract was washed with 1N aqueous solution of sodium hydroxide and water
5. customAfter drying
6. concentrationthe mixture was concentrated under reduced pressure
7. customto give crystals, which
8. customwere recrystallized from isopropyl ether