Hydrochloric Acid → HCID 178501087, compound

Participants

Reaction Steps

Potassium tert-butoxide (37.7 g) was added to a solution (200 ml) of a cis- and trans- mixture of methyl (+)-4-(1-acetamidoethyl)cyclohexanecarboxylate (38.0 g) in methanol and the mixture was refluxed under heating for 60 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue obtained was poured into ice water, neutralized with conc. hydrochloric acid and extracted with chloroform. The extract was washed with water, dried and concentrated under reduced pressure to give 21 g of methyl (+)-trans-4-(1-acetamidoethyl)cyclohexanecarboxylate. [α]D =+41.6° (methanol, c=1)

Provenance & Evidence