HCID 57752702, compound → HCID 57752701, compound

Participants

Reaction Steps

A solution of 8-(1-ethyl-propyl)-3-(7-isopropenyl-2-methyl-benzo[b]thiophen-3-yl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (33 mg, 0.08 mmol) in CH3OH (25 mL) is hydrogenated at 30 psi/RT/1 h using 10% Pd—C (99 mg). The reaction mixture is filtered through celite, washed with EtOAc and concentrated to give the title compound (13.6 mg, 0.03 mmol, 41%). 1H NMR (CDCl3): δ 0.92 (t, J=7.5 Hz, 6H), 1.42 (d, J=2.6 Hz, 3H), 1.44 (d, J=2.6 Hz, 3H), 1.75-1.95 (m, 4H), 2.40 (s, 3H), 2.41 (s, 3H), 2.45 (s, 3H), 3.20-3.30 (m, 1H), 3.35-3.50 (m, 1H), 6.69 (s, 1H), 7.07 (d, J=7.5 Hz, 1H), 7.18 (d, J=7.0 Hz, 1H), 7.26 (t, J=7.9 Hz, 1H) ppm. ES-MS (m/z): calcd for C25H31N3S (M+H)+: 406.6. found: 406.3.

Provenance & Evidence