Sodium Hydroxide → HCID 178513000, compound

HRID 2260573Notes

Reaction equation

HRID 2260573 reaction equation
S(O)(O)(=O)=O.[NH2:6][C:7](=[NH:9])S.[OH-].[Na+].[NH2:12][CH2:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([C:20]([OH:22])=[O:21])[CH2:16][CH2:15]1>O>[NH:12]([CH2:13][C@H:14]1[CH2:15][CH2:16][C@H:17]([C:20]([OH:22])=[O:21])[CH2:18][CH2:19]1)[C:7]([NH2:9])=[NH:6]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 178511262HCID 178511262, compoundHCID 178513471HCID 178513471, compound

Product 1

HCID 178513000HCID 178513000, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Isothiourea sulfate (21.2 g) was dissolved in water (40 ml) and a 2N solution of sodium hydroxide (46 ml) was dropwise added under ice-cooling. The mixture was stirred at said temperature for 30 minutes and trans-4-aminomethylcyclohexanecarboxylic acid dissolved in boiling water (100 ml) was dropwise added and the mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction mixture was cooled and the resultant crystals were collected by filtration. The crystals were thoroughly washed with cold water and dried to give 18.5 g of trans-4-guanidinomethylcyclohexanecarboxylic acid, melting point 325° C.

Workup

  1. temperaturecooling
  2. customfor 30 minutes
  3. additionwas dropwise added
  4. stirringthe mixture was stirred at room temperature for 24 hours
  5. customAfter completion of the reaction
  6. temperaturethe reaction mixture was cooled
  7. filtrationthe resultant crystals were collected by filtration
  8. washThe crystals were thoroughly washed with cold water
  9. customdried

Sources & evidence

ORD record
ord-5fb18ca0e18446e4902e37ba5e98ab72
Source dataset
uspto-grants-1995_12
Patent number
US05478838

Reaction notes

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