2-Chloro-6-methylaniline → HCID 10068195, compound

HRID 2260580Notes

Reaction equation

HRID 2260580 reaction equation
[CH3:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11](O)=[O:12])[C:4]=2[CH:3]=1.[Cl:20][C:21]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[C:22]=1[NH2:23]>>[Cl:20][C:21]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[C:22]=1[NH:23][C:11]([CH:10]1[C:9]2[CH:14]=[CH:15][CH:16]=[CH:17][C:8]=2[CH2:7][O:6][C:5]2[CH:18]=[CH:19][C:2]([CH3:1])=[CH:3][C:4]1=2)=[O:12]

Participants

3

Reactant 2

HCID 68972-Chloro-6-methylanilineHCID 101063426,11-Dihydro-2-methyldibenz[b,e]-oxepin-11-carboxylic acid

Product 1

HCID 10068195HCID 10068195, compoundYield 80.2%

Procedure

The similar procedures as in Example 1 were repeated except using 1.40 g of Compound A and 0.72 g of 2-chloro-6-methylaniline in place of aniline to obtain 1.54 g of Compound 8.

Sources & evidence

ORD record
ord-49b5f0dd33e04457988ca120d74012b1
Source dataset
uspto-grants-1995_12
Patent number
US05478835

Reaction notes

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