2-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid → 2-Bromo-6,11-dihydro-N-(2,6-diisopropyl-4-methylthiophenyl)dibenz[b,e]oxepin-11-carboxamide

HRID 2260597Notes

Reaction equation

HRID 2260597 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11]([OH:13])=O)[C:4]=2[CH:3]=1.[CH:20]([C:23]1[CH:29]=[C:28]([S:30][CH3:31])[CH:27]=[C:26]([CH:32]([CH3:34])[CH3:33])[C:24]=1[NH2:25])([CH3:22])[CH3:21]>>[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:9]=[CH:14][CH:15]=[CH:16][C:17]=3[CH:10]([C:11]([NH:25][C:24]3[C:26]([CH:32]([CH3:34])[CH3:33])=[CH:27][C:28]([S:30][CH3:31])=[CH:29][C:23]=3[CH:20]([CH3:22])[CH3:21])=[O:13])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 104036412-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid2×HCID 189985052,6-Diisopropyl-4-methylthioaniline

Product 1

HCID 189985092-Bromo-6,11-dihydro-N-(2,6-diisopropyl-4-methylthiophenyl)dibenz[b,e]oxepin-11-carboxamideYield 76.1%

Procedure

The similar procedures as in Example 1 were repeated except using 1.0 g of 2-bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid obtained in Example 46 (Compound H) in place of Compound A and 0.84 g of 2,6-diisopropyl-4-methylthioaniline in place of aniline to obtain 1.25 g of Compound 44.

Sources & evidence

ORD record
ord-895def2ca98744778549d438639408ee
Source dataset
uspto-grants-1995_12
Patent number
US05478835

Reaction notes

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