HCID 22413837, compound → HCID 18998770, compound

HRID 2260615Notes

Reaction equation

HRID 2260615 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:13])[N:9]2[CH3:12])=[CH:4][C:3]=1I.[OH:15][C@:16]1([C:23]2[CH:24]=[C:25]([SH:28])[S:26][CH:27]=2)[CH2:21][CH2:20][O:19][C@@H:18]([CH3:22])[CH2:17]1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:13])[N:9]2[CH3:12])=[CH:4][C:3]=1[S:28][C:25]1[S:26][CH:27]=[C:23]([C:16]2([OH:15])[CH2:21][CH2:20][O:19][CH:18]([CH3:22])[CH2:17]2)[CH:24]=1

Participants

3

Reactant 2

HCID 22413837HCID 22413837, compoundHCID 53946220HCID 53946220, compound

Product 1

HCID 18998770HCID 18998770, compoundYield 85%

Procedure

Using an analogous procedure to that described in Example 5, 7-fluoro-6-iodo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with (2S,4R)-4-hydroxy-4-(2-mercaptothien-4-yl)-2-methyltetrahydropyran to give 4-[2-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)thien-4-yl]-4-hydroxy-2-methyltetrahydropyran in 85% yield as a gum;

Sources & evidence

ORD record
ord-d015860561304460a4cedb14c1afcc60
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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