HCID 22413805, compound → HCID 18998744, compound

HRID 2260617Notes

Reaction equation

HRID 2260617 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]2.[OH:14][C:15]1([C:23]2[CH:24]=[C:25]([SH:28])[S:26][CH:27]=2)[CH2:20][CH:19]([CH3:21])[O:18][CH:17]([CH3:22])[CH2:16]1>>[OH:14][C:15]1([C:23]2[CH:24]=[C:25]([S:28][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]4)[S:26][CH:27]=2)[CH2:16][CH:17]([CH3:22])[O:18][CH:19]([CH3:21])[CH2:20]1

Participants

3

Reactant 2

HCID 22413805HCID 22413805, compoundHCID 22413816HCID 22413816, compound

Product 1

HCID 18998744HCID 18998744, compoundYield 62%

Procedure

Using an analogous procedure to that described in Example 5, 6-iodo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 4-hydroxy-4-(2-mercaptothien-4-yl)-2,6-dimethyltetrahydropyran to give 4-hydroxy-2,6-dimethyl-4-[2-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)thien-4-yl]tetrahydropyran in 62% yield as a foam;

Sources & evidence

ORD record
ord-5d25b0af6bb54ffe8899c91f7d4ed064
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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