HCID 22413835, compound → HCID 22860812, compound

HRID 2260618Notes

Reaction equation

HRID 2260618 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH:6]=[CH:5]2.[OH:14][C@:15]1([C:22]2[CH:23]=[C:24]([SH:27])[S:25][CH:26]=2)[CH2:20][CH2:19][O:18][C@@H:17]([CH3:21])[CH2:16]1>>[OH:14][C@:15]1([C:22]2[CH:23]=[C:24]([S:27][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH3:12])[C:7](=[O:13])[CH:6]=[CH:5]4)[S:25][CH:26]=2)[CH2:20][CH2:19][O:18][C@@H:17]([CH3:21])[CH2:16]1

Participants

3

Reactant 2

HCID 22413835HCID 22413835, compoundHCID 53946220HCID 53946220, compound

Product 1

HCID 22860812HCID 22860812, compoundYield 65%

Procedure

Using an analogous procedure to that described in Example 5, 6-iodo-1-methyl-1,2-dihydroquinolin-2-one (European Patent Application No. 0420511, Example 1 thereof) was reacted with (2S,4R)-4-hydroxy-4(2-mercaptothien-4-yl)-2-methyltetrahydropyran to give (2S,4R)-4-hydroxy-2-methyl-4-[2-(1-methyl-2-oxo-1,2-dihydroquinolin-6-ylthio)thien-4-yl]tetrahydropyran in 65% yield as a foam;

Sources & evidence

ORD record
ord-e80bc9435abb40bcbc960c064f0c00e7
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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