HCID 22413747, compound → HCID 56986881, compound

HRID 2260620Notes

Reaction equation

HRID 2260620 reaction equation
[F:1][C:2]1[CH:3]=[C:4](I)[CH:5]=[C:6]2[C:11]=1[N:10]([CH3:12])[C:9](=[O:13])[CH2:8][CH2:7]2.[OH:15][C@:16]1([C:23]2[CH:24]=[C:25]([SH:28])[S:26][CH:27]=2)[CH2:21][CH2:20][O:19][C@@H:18]([CH3:22])[CH2:17]1>>[F:1][C:2]1[CH:3]=[C:4]([S:28][C:25]2[S:26][CH:27]=[C:23]([C@@:16]3([OH:15])[CH2:21][CH2:20][O:19][C@@H:18]([CH3:22])[CH2:17]3)[CH:24]=2)[CH:5]=[C:6]2[C:11]=1[N:10]([CH3:12])[C:9](=[O:13])[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 22413747HCID 22413747, compoundHCID 53946220HCID 53946220, compound

Product 1

HCID 56986881HCID 56986881, compoundYield 40%

Procedure

Using an analogous procedure to that described in Example 5, 8-fluoro-6-iodo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one with (2S,4R)-4-hydroxy-4-(2-mercaptothien-4-yl)-2-methyltetrahydropyran to give (2S,4R)-4-[2-(8-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)thien-4-yl]-4-hydroxy-2-methyltetrahydropyran in 40% yield as a foam;

Sources & evidence

ORD record
ord-9d9d9a9522f242b5b3a41f1271af3a73
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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