HCID 22413805, compound → HCID 18998776, compound

HRID 2260622Notes

Reaction equation

HRID 2260622 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]2.[OH:14][C:15]1([C:23]2[CH:24]=[C:25]([SH:28])[S:26][CH:27]=2)[CH2:20][CH2:19][O:18][C:17]([CH3:22])([CH3:21])[CH2:16]1>>[OH:14][C:15]1([C:23]2[CH:24]=[C:25]([S:28][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]4)[S:26][CH:27]=2)[CH2:20][CH2:19][O:18][C:17]([CH3:21])([CH3:22])[CH2:16]1

Participants

3

Reactant 2

HCID 22413805HCID 22413805, compoundHCID 22413809HCID 22413809, compound

Product 1

HCID 18998776HCID 18998776, compoundYield 72%

Procedure

Using an analogous procedure to that described in Example 5, 6-iodo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 4-hydroxy-4-(2-mercaptothien-4-yl)-2,2-dimethyltetrahydropyran to give 4-hydroxy-2,2-dimethyl-4-[2-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)thien-4-yl]tetrahydropyran in 72% yield as a foam;

Sources & evidence

ORD record
ord-3aa376a2dc1942e9a2bdc915a1b64cc3
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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