HCID 18998756, compound → HCID 18998730, compound

HRID 2260624Notes

Reaction equation

HRID 2260624 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]2.[OH:14][C:15]1([C:23]2[CH:24]=[C:25]([SH:28])[S:26][CH:27]=2)[CH2:21][CH:20]2[O:22][CH:17]([CH2:18][CH2:19]2)[CH2:16]1>>[OH:14][C:15]1([C:23]2[CH:24]=[C:25]([S:28][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]4)[S:26][CH:27]=2)[CH2:21][CH:20]2[O:22][CH:17]([CH2:18][CH2:19]2)[CH2:16]1

Participants

3

Reactant 2

HCID 18998756HCID 18998756, compoundHCID 22413805HCID 22413805, compound

Product 1

HCID 18998730HCID 18998730, compoundYield 28%

Procedure

Using an analogous procedure to that described in Example 5, 6-iodo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 3-hydroxy-3-(2-mercaptothien-4-yl)-8-oxabicyclo[3,2,1]octane to give 3-hydroxy-3-[2-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)thien-4-yl]-8-oxabicyclo[3,2,1]octane in 28% yield.

Sources & evidence

ORD record
ord-c3eaac1e032a4f459dc2d722e0e6605f
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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