HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromobenzene → (2S,4R)-4-hydroxy-4-(3-bromophenyl)-2-methyltetrahydropyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromobenzene | HCID 7927 | — |
| Reactant | (2S)-2-Methyloxan-4-one | HCID 10125057 | — |
| Product | (2S,4R)-4-hydroxy-4-(3-bromophenyl)-2-methyltetrahydropyran | HCID 54527261 | 66% |
Reaction Steps
Using an analogous procedure to that described in the portion of Example 6 which is concerned with the preparation of starting materials, 1,3-dibromobenzene was reacted with (2S)-2-methyltetrahydropyran-4-one to give (2S,4R)-4-hydroxy-4-(3-bromophenyl)-2-methyltetrahydropyran in 66% yield as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05478842 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-03f4a6bf89d74e4ea69a6cefda6e4e76 |
| Source note | uspto-grants-1995_12 |