HCID 22413786, compound → HCID 22860810, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 5, 6-iodo-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydroquinazoline was reacted with (2S,4R)-4-hydroxy-4-(2-mercaptothien-4-yl)-2-methyltetrahydropyran to give (2S,4R)-4-hydroxy-2-methyl-4-[2-(1,3-dimethyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-ylthio)thien-4-yl]tetrahydropyran in 74% yield as a gum;

Provenance & Evidence