HCID 22413796, compound → HCID 18998742, compound

HRID 2260632Notes

Reaction equation

HRID 2260632 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]2.[OH:14][C:15]1([C:21]2[CH:22]=[C:23]([SH:26])[S:24][CH:25]=2)[CH2:19][CH2:18][O:17][CH:16]1[CH3:20]>>[OH:14][C:15]1([C:21]2[CH:22]=[C:23]([S:26][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]4)[S:24][CH:25]=2)[CH2:19][CH2:18][O:17][CH:16]1[CH3:20]

Participants

3

Reactant 2

HCID 22413796HCID 22413796, compoundHCID 22413805HCID 22413805, compound

Product 1

HCID 18998742HCID 18998742, compoundYield 42%

Procedure

Using an analogous procedure to that described in Example 5, 6-iodo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with (2RS,3SR)-3-hydroxy-3-(2-mercaptothien-4-yl)-2-methyltetrahydrofuran to give (2RS,3SR)-3-hydroxy-2-methyl-3-[2-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)thien-4-yl]tetrahydrofuran in 42% yield as a foam;

Sources & evidence

ORD record
ord-4f15bb05d4794e98aaacc0f11b512d26
Source dataset
uspto-grants-1995_12
Patent number
US05478842

Reaction notes

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