HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Isocyanato-1,2,3-trimethoxybenzene → 1-[3-(3, 4,5-trimethoxyphenylcarbamoyloxy)-propyl]-4-(6-fluoro-1-methyl-1H-indazol-3-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Isocyanato-1,2,3-trimethoxybenzene | HCID 517766 | — |
| Reactant | 4-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine | HCID 18998799 | — |
| Product | 1-[3-(3, 4,5-trimethoxyphenylcarbamoyloxy)-propyl]-4-(6-fluoro-1-methyl-1H-indazol-3-yl)piperidine | HCID 18998804 | 68% |
Reaction Steps
Starting from 4-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxyprop-1-yl)piperidine (300 mg, 1.03 mmol) and 3,4,5-trimethoxyphenylisocyanate (300 mg, 1.44 mmol) using the procedure described in example 1B was prepared 350 mg (68%) of the title compound. M.p. 85°-88° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05478845 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-6ef8e159613e4840ac4755600750d7eb |
| Source note | uspto-grants-1995_12 |