HCID 53964150, compound → HCID 86749174, compound

Participants

Reaction Steps

A suspension of 5-(4-(2-phthalimidoethoxy)benzylidene)-2,4-thiazolidinedione (3.25 g) in dioxan (100 ml)was hydrogenated at room temperature and pressure in the presence of 10% palladium-charcoal (5 g) for 18 hours. A further portion of catalyst (5 g) was added, and the reaction continued for a total of 23 hours. The reaction mixture was filtered through diatomaceous earth, and the solvent evaporated. The resulting gum was crystallised from methanol-dioxan to afford the title compound, mp 192°-4° C.

Provenance & Evidence