Benzoic Acid → HCID 73504064, compound

Participants

Reaction Steps

A mixture of 4-[2-(5-phenyl-2,4-thiazolidinedion-3-yl) ethoxy]-benzaldehyde) (1.5 g) 2,4-thiazolidinedione (0.54 g), piperidine (0.4 ml) and benzoic acid (0.2 g) was heated at reflux in toluene (100 ml) in a Dean and Stark apparatus. After 4 hours at reflux the mixture was allowed to cool to room temperature overnight and then evaporated to dryness. The residue was then triturated with diisopropyl ether for 24 hours. The resulting solid was filtered off, washed with ether and dried in vacuo to afford the title compound which softened at 80° C. and melted at 120° C.

Provenance & Evidence