反应详情

Ethyl benzoate (16.0 g, 15.3 ml) was dissolved in 2-(N-methylamino)ethanol (200 ml) and the mixture heated at reflux for 17.5 hours, cooled and diluted with water (1 l). The mixture was extracted with dichloromethane (4×200 ml), and the combined dichloromethane solutions washed with brine (300 ml), dried (MgSO4) and evaporated. The title compound, an oil, was used without further purification.

1. temperaturethe mixture heated
2. temperatureat reflux for 17.5 hours
3. temperaturecooled
4. extractionThe mixture was extracted with dichloromethane (4×200 ml)
5. washthe combined dichloromethane solutions washed with brine (300 ml)
6. dry with materialdried (MgSO4)
7. customevaporated
8. customThe title compound, an oil, was used without further purification