反应详情

5-(4-[2-(N-Benzoyl-N-methylamino)ethoxy]benzylidene)-2,4-thiazolidinedione (4.01 g) was dissolved in dioxan (400 ml) and hydrogenated at room temperature and pressure in the presence of 10% palladium-charcoal (4 g) for 3.5 hours. A further portion of catalyst (4 g) was added, and the reaction continued for a total of 52 hours. The reaction mixture was filtered through diatomaceous earth, and the solvent evaporated. The resulting gum was recrystallised from dichloromethane-diethyl ether to afford the title compound, mp 139-142° C.

1. customcontinued for a total of 52 hours
2. filtrationThe reaction mixture was filtered through diatomaceous earth
3. customthe solvent evaporated
4. customThe resulting gum was recrystallised from dichloromethane-diethyl ether