Etodroxizine → Norchlorcyclizine

HRID 2260813Notes

Reaction equation

HRID 2260813 reaction equation
C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[N:23]2[CH2:28][CH2:27][N:26](CCOCCOCCO)[CH2:25][CH2:24]2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([CH:22]([C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:23]2[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 63345Etodroxizine2×HCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

Product 1

HCID 9340Norchlorcyclizine

Procedure

dextrorotatory dihydrochloride of 2-[2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethoxy]ethanol (compound J, prepared in Example 5.8);

Sources & evidence

ORD record
ord-59180950058e4b92ad6ebd07e5d7deb5
Source dataset
uspto-grants-1995_12
Patent number
US05478941

Reaction notes

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