Tetrahydrofuran → 4-[(2-Butyl-4-quinolinyl)-methyl]-benzonitrile

Participants

Reaction Steps

Using the procedure of Step G of Example 1, 0.614 g of 4-chloro-2-butyl quinoline of Step D, 0.8 ml of tetrahydrofuran, 0.323 g of tetrakis triphenylphosphine palladium and 10 ml of a 0.5M 4-bromomethyl benzonitrile zinc solution in tetrahydrofuran were reacted to obtain after chromatography on silica (eluant: hexane--ethyl acetate (8-2)) 0.781 g of the desired product.

Provenance & Evidence