Water → 4-[(2-Butyl-4-quinolinyl)-methyl]-benzoic acid

HRID 2260820Notes

Reaction equation

HRID 2260820 reaction equation
[CH2:1]([C:5]1[CH:14]=[C:13]([CH2:15][C:16]2[CH:23]=[CH:22][C:19]([C:20]#N)=[CH:18][CH:17]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4].[OH-:24].[Na+].[OH2:26]>>[CH2:1]([C:5]1[CH:14]=[C:13]([CH2:15][C:16]2[CH:23]=[CH:22][C:19]([C:20]([OH:26])=[O:24])=[CH:18][CH:17]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 189990714-[(2-Butyl-4-quinolinyl)-methyl]-benzonitrile

Product 1

HCID 189990734-[(2-Butyl-4-quinolinyl)-methyl]-benzoic acid

Procedure

Using the procedure of Example 2, 0.750 g of the product of Example 3 and 2.5 ml of water and 2.5 ml of sodium hydroxide were reacted to obtain 205 mg of the desired product which after crystallization melted at 158° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f28fdd3725db4042973da3cb2d907be7
Source dataset
uspto-grants-1995_12
Patent number
US05478938

Reaction notes

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