HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzoyl chloride → HCID 748006, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzoyl chloride | HCID 80172 | — |
| Reactant | Ethyl 2-amino-4-methyl-1,3-thiazole-5-carboxylate--hydrogen chloride (1/1) | HCID 2775303 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 748006 | HCID 748006 | 82.6% |
Reaction Steps
A mixture of 4-cyanobenzoyl chloride (166.5 g), ethyl 2-amino-4-methylthiazole-5-carboxylate hydrochloride (224.0 g) and pyridine (2000 ml) was stirred at room temperature for 70 minutes. The precipitated crystals were collected by filtration, and washed with 3% hydrochloric acid and water to give ethyl 2-(4-cyanobenzoylamino)-4-methylthiazole-5-carboxylate (262.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05478945 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-686a91b6572d4030b752b815f7a669bd |
| Source note | uspto-grants-1995_12 |