HCID 74018133, compound → HCID 23118810, compound

HRID 2260915Notes

Reaction equation

HRID 2260915 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH3:11])[CH:5]=[C:4]([CH3:12])[C:3]=1[CH:13]=[CH:14][CH:15]1[CH2:20][CH2:19][CH:18]([CH:21]2[CH2:26][CH2:25][CH:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:23][CH2:22]2)[CH2:17][CH2:16]1.[H][H]>C1(C)C=CC=CC=1.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH3:11])[CH:5]=[C:4]([CH3:12])[C:3]=1[CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][CH:18]([CH:21]2[CH2:26][CH2:25][CH:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:23][CH2:22]2)[CH2:17][CH2:16]1

Participants

5

Reactant 2

HCID 74018133HCID 74018133, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23118810HCID 23118810, compoundYield 50.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1140TolueneSolvent

Procedure

0.08 g of Pd/C was added to 1.65 g of the compound 1-3-3-10 having been dissolved in 12.5 mL of toluene and 12.5 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 0.83 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-pentylcyclohexyl)cyclohexyl)ethane (Compound 1-3-3-2) as colorless crystals.

Workup

  1. customwas not absorbed
  2. customPd/C was removed
  3. distillationthe solvent was distilled off
  4. customThe residue was purified by silica gel column chromatography and recrystallization

Sources & evidence

ORD record
ord-5393769222a44220976c8ccffea6e5a5
Source dataset
uspto-grants-2010_12
Patent number
US07846513B2

Reaction notes

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