反应详情

To a solution of 3-methoxythioanisole (3.084 g, 20 mmol) in 300 mL acetone was added a solution of oxone (30.74 g, 50 mmol) in 125 mL water, resulting in the formation of a white precipitate. Stirring continued overnight, and the solid was filtered off and washed with acetone. Filtrate was concentrated to remove acetone. Aqueous layer was extracted with EtOAc (2×200 mL) and dried over Na2SO4. The solvent was removed to give 1-methanesulfonyl-3-methoxy benzene (3.68 g, 98%) as oil.

1. customresulting in the formation of a white precipitate
2. filtrationthe solid was filtered off
3. washwashed with acetone
4. concentrationFiltrate was concentrated
5. customto remove acetone
6. extractionAqueous layer was extracted with EtOAc (2×200 mL)
7. dry with materialdried over Na2SO4
8. customThe solvent was removed