Pyridine → 2-Pyridyl Trifluoromethanesulfonate

Participants

Reaction Steps

In analogy to GP 2, reaction of 3.51 g Intermediate 1.1 (11.8 mmol, 1 eq.), 1.43 mL dry pyridine (17.7 mmol, 1.5 eq.), 2.98 ml trifluoromethanesulfonic acid anhydride (17.7 mmol, 1.5 eq.) in 95 mL DCM yielded 4.42 g 2-pyridyl triflate (10.4 mmol, 88% yield).

Provenance & Evidence