Pyridine → 2-Pyridyl Trifluoromethanesulfonate

Participants

Reaction Steps

In analogy to GP 2, reaction of 7.2 g Intermediate 1.6 (20.4 mmol, 1 eq.), 2.5 mL dry pyridine (30.6 mmol, 1.5 eq.), 5.14 ml trifluoromethanesulfonic acid anhydride (30.6 mmol, 1.5 eq.) in 320 mL DCM yielded 4.2 g 2-pyridyl triflate (8.65 mmol, 43% yield).

Provenance & Evidence