Triethylamine → HCID 59592761, compound

Participants

Reaction Conditions

Reaction Steps

900 mg of 6-bromomethyl-1-methyl-4-(4-nitro-phenyl)-1H-pyrazolo[3,4-b]pyridine (Intermediate 17.7; 2.59 mmol, 1 eq.) were dissolved in 13.5 mL DMF and treated sequentially with 0.54 mL Et3N (3.9 mmol, 1.5 eq.) and 0.35 mL methyl piperazine (3.11 mmol, 1.2 eq.). The reaction mixture was heated to 90° C. for 45 min, partitioned between CH2Cl2 and water, the aqueous layer was re-extracted and the combined organic layers were dried and concentrated in vacuo to yield the crude piperazine product, which was used without further purification.

Provenance & Evidence