Sodium methanesulfinate → HCID 59592702, compound

Participants

Reaction Steps

1.04 g 6-bromomethyl-1-methyl-4-(4-nitro-phenyl)-1H-pyrazolo[3,4-b]pyridine (Intermediate 13.1; 3 mmol, 1 eq.) were dissolved in 55 mL 10:1 EtOH/DMF, treated with 459 mg sodium methanesulfinate (4.5 mmol, 1.5 eq.) and refluxed for 150 min. The mixture was cooled to rt and concentrated in vacuo. Addition of water was followed by precipitation to yield 1040 mg of the crude product (quantitative yield).

Provenance & Evidence