HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 24797451, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178438791 | HCID 178438791 | — |
| Product | HCID 24797451 | HCID 24797451 | 74.5% |
Reaction Steps
In analogy to GP 6, reaction of 100 mg of 1-[4-(3-Amino-6-isopropyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea (0.22 mmol, 1 eq.) with 35 μL concentrated sulphuric acid and 37 mg sodium nitrite (2.5 eq.) yielded 72 mg of the desired product (74% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846928B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-44524b4f85124941bd26b0fae8d27b68 |
| Source note | uspto-grants-2010_12 |