Sulfuric Acid → HCID 24797452, compound

Participants

Reaction Steps

In analogy to GP 6, reaction of 200 mg of 1-[4-(3-Amino-6-isopropyl-1-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea (0.43 mmol, 1 eq.) with 67 μL concentrated sulphuric acid and 146 mg sodium nitrite (5 eq.) yielded 23 mg of the desired product (12% yield).

Provenance & Evidence