反应详情

温度

180 °C

A mixture of 4-amino isophthalic acid (17 g, 0.093 mol) and formamide (85 mL) was heated at 180° C. for 5 h. The reaction mixture was cooled to RT and added acetone. The solid precipitate thus obtained was stirred for 2 h, filtered and dried to give 4-oxo-3,4-dihydroquinazoline-6-carboxylic acid (11 g, 61%).

1. temperatureThe reaction mixture was cooled to RT
2. customThe solid precipitate thus obtained
3. filtrationfiltered
4. customdried