HCID 82338196, compound → HCID 59592656, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of PCC (4.2 g, 0.019 mol) and celite (4 g) in dry CH2Cl2 (100 mL) was cooled to 0° C. and slowly added a solution of methyl-[6-(hydroxymethyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetate (1.2 g, 0.0048 mol) in CH2Cl2 (30 mL) under N2. The reaction mixture was stirred at RT for 2 h, passed through celite, washed with CH2Cl2 (50 mL) and concentrated to give crude product, which was purified on silica gel affording 1.05 g (87%).

Provenance & Evidence