Thiazolidinedione → 5-[(4-Phenylquinazolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione

HRID 2261123Notes

Reaction equation

HRID 2261123 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([CH:17]=O)[CH:15]=3)[N:10]=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:19]1[CH2:23][C:22](=[O:24])[NH:21][C:20]1=[O:25]>>[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([CH:17]=[C:23]4[S:19][C:20](=[O:25])[NH:21][C:22]4=[O:24])[CH:15]=3)[N:10]=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 5437ThiazolidinedioneHCID 574696424-Phenylquinazoline-6-carbaldehyde2×

Product 1

HCID 713782615-[(4-Phenylquinazolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione

Procedure

Following the general method as outlined in Example 1, starting from 4-Phenyl-quinazoline-6-carbaldehyde (intermediate 13) and 1,3-thiazolidine-2,4-dione, the title compound was obtained.

Sources & evidence

ORD record
ord-42c20083f29243e08a18fb614e489b1f
Source dataset
uspto-grants-2010_12
Patent number
US07846925B2

Reaction notes

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