Thiazolidinedione → 5-[(4-Methoxyquinazolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione

HRID 2261127Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:13]=O)[CH:11]=2)[N:6]=[CH:5][N:4]=1.[S:15]1[CH2:19][C:18](=[O:20])[NH:17][C:16]1=[O:21]>>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:13]=[C:19]3[S:15][C:16](=[O:21])[NH:17][C:18]3=[O:20])[CH:11]=2)[N:6]=[CH:5][N:4]=1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 574696374-Methoxyquinazoline-6-carbaldehyde2×

Product 1

HCID 713782545-[(4-Methoxyquinazolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione

Procedure

Following the general method as outlined in Example. 1, starting from 4-methoxy-quinazoline-6-carbaldehyde (intermediate 10) and 1,3-thiazolidine-2,4-dione, the title compound was obtained.

Sources & evidence

ORD record: ord-ec1c767e7b864193a5a3550ace13a7ea
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07846925B2

Reaction notes

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