HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2261132Generated: October 31, 2026
Formic Acid → 5-[(1-Ethyl-1H-benzimidazol-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
https://huagongshe.com/reaction/2261132
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 5-{[4-Amino-3-(ethylamino)phenyl]methylidene}-1,3-thiazolidine-2,4-dione | HCID 71378271 | — |
| Product | 5-[(1-Ethyl-1H-benzimidazol-6-yl)methylidene]-1,3-thiazolidine-2,4-dione | HCID 71378253 | 63% |
Reaction Steps
5(4-Amino-3-ethylamino-benzylidene)-thiazolidine-2,4-dione (50 mg, 0.19 mmol) (intermediate 36) was dissolved in formic acid (5 mL) and the solution stirred at 100° C. over night. Formic acid was then removed in vacuo. The crude residue was then purified by silica gel column to give the title compound (35 mg, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07846925B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-06f8c6e7ee794d63a1ae3c070bed1184 |
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| Source note | uspto-grants-2010_12 |
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