Oxazolo(4,5-b)pyridin-2(3H)-one → HCID 131728561, compound

HRID 2261181Notes

Reaction equation

HRID 2261181 reaction equation
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2]1=[O:10].N([CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)=C=O>O1CCOCC1>[O:10]=[C:2]1[NH:3][C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[O:1]1.[CH2:19]1[CH2:18][CH2:17][CH2:16][CH:15]([CH2:14][C:2]([NH2:3])=[O:1])[CH2:20]1

Participants

4

Reactant 2

HCID 2799900Oxazolo(4,5-b)pyridin-2(3H)-oneHCID 3414518(Isocyanatomethyl)cyclohexane

Product 1

HCID 131728561HCID 131728561, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

100 mg (0.735 mmol) of 3H-oxazolo[4,5-b]pyridin-2-one were reacted in analogy to Example 1 with 102 mg (0.735 mmol) of isocyanatomethylcyclohexane in dioxane at 80° C. Yield: 43 mg (21%), M+H+: 276.13.

Sources & evidence

ORD record
ord-909c3182f9094dbf82d17cfc28daa4b2
Source dataset
uspto-grants-2010_12
Patent number
US07846943B2

Reaction notes

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