反应详情

温度

120 °C

Acetic anhydride (0.123 mL, 1.3 mmol) is added to (3-(9-ethyl-8-imino-8,9-dihydro-3H-3,4,9-triaza-cyclopenta[a]naphthalen-7-yl)-5-methoxy-benzoic acid ethyl ester (100 mg, 0.26 mmol) in sealed tube and heated at 120° C. for 2.5 hr. The acetic anhydride is evaporated and 6N HCl (3 mL) is added and the mixture is again heated at 105° C. for 1 hr. The reaction mixture is brought to room temperature and poured in ice cold water. The acid is crystallized out and filtered. It is washed with water and dried to give the desired product. MS m/z 364.2 (M+1).

1. customThe acetic anhydride is evaporated
2. addition6N HCl (3 mL) is added
3. temperaturethe mixture is again heated at 105° C. for 1 hr
4. customis brought to room temperature
5. additionpoured in ice cold water
6. customThe acid is crystallized out
7. filtrationfiltered
8. washIt is washed with water
9. customdried