反应详情

A solution of 3-(3-chlorosulfonylphenyl)acrylic acid methyl ester (3) (0.640 g, 2.45 mmol) in dichloromethane (2 ml) was added to a mixture of aniline (0.465 g, 4.99 mmol) and pyridine (1 ml), and the resultant solution was stirred at 50° C. for one hour. The reaction mixture was evaporated and the residue was partitioned between ethyl acetate and 10% HCl. The organic layer was washed successively with water, saturated NaCl, and dried (Na2SO4). The solvent was removed and the residue was chromatographed on silica gel with chloroform-ethyl acetate (7:1, v/v) as eluent. The obtained product was washed with diethyl ether to give the title compound (0.226 g, 29%). 1H NMR (CDCl3, HMDSO), δ: 3.72 (3H, s); 6.34 (1H, d, J=16.0 Hz); 6.68 (1H, br s); 6.92-7.89 (10H, m).

1. customThe reaction mixture was evaporated
2. customthe residue was partitioned between ethyl acetate and 10% HCl
3. washThe organic layer was washed successively with water, saturated NaCl
4. dry with materialdried (Na2SO4)
5. customThe solvent was removed
6. customthe residue was chromatographed on silica gel with chloroform-ethyl acetate (7:1
7. washThe obtained product was washed with diethyl ether