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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2261207Generated: November 3, 2026

5-(Bromomethyl)thiophene-2-carbonitrile → 5-[3-Fluoro-4-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenoxymethyl]-thiophene-2-carbonitrile

https://huagongshe.com/reaction/2261207

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Bromomethyl)thiophene-2-carbonitrileHCID 10560016—
Reactant(2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 59259534—
Product5-[3-Fluoro-4-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenoxymethyl]-thiophene-2-carbonitrileHCID 11495301—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure B using (2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 5-bromomethyl-thiophene-2-carbonitrile [CAS 134135-41-4]. MS (ES+) m/e 414.2

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07846950B2
Source datasetuspto-grants-2010_12
ORD IDord-74a06cbf1c2543599927838517695e04
Source noteuspto-grants-2010_12