4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 11589482, compound

HRID 2261209Notes

Reaction equation

HRID 2261209 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Cl.Cl[CH2:15][C:16]1[N:17]=[CH:18][S:19][CH:20]=1.[CH3:21][C@@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[CH2:27][C@@H:28]1[CH2:32][CH2:31][CH2:30][NH:29]1>>[F:11][C:5]1[CH:6]=[C:7]([O:10][CH2:15][C:16]2[N:17]=[CH:18][S:19][CH:20]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:29]1[CH2:30][CH2:31][CH2:32][C@H:28]1[CH2:27][N:23]1[CH2:24][CH2:25][CH2:26][C@H:22]1[CH3:21])=[O:12]

Participants

4

Reactant 3

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 22463192Methyl 2-fluoro-4-hydroxybenzoateHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 11589482HCID 11589482, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 4-(chloromethyl)thiazole hydrochloride [CAS 7709-58-2], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 404.2

Sources & evidence

ORD record
ord-7f2ee35300124c48bcb3a01d529faf7e
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

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